Composite Glandular and NeuroendocrineCarcinoma of the Stomach-Two Case Reports

Introduction: Neuroendocrine tumors develop throughout gastrointestinal tract. The concurrence of mixed adenocarcinoma and neuroendocrine tumor together in the stomach is rare. Case report: We report two cases of poorly differentiated carcinoma stomach with neuroendocrine component. These patients underwent radical total gastrectomy with D2 lymph node dissection followed by adjuvant chemotherapy. They are asymptomatic and disease free on follow -up. Conclusion: Combination of neuroendocrine tumours and adenocarcinoma stomach a rare entity. Pre operative diagnosis with endoscopic biopsy is difficult. However, if there is a suspicion based on endoscopic biopsy, and then Immunohistochemical staining for neuroendocrine tumor markers may help in establishing preoperative diagnosis.